Pubblicazioni

Effectiveness of repetitive transcranial magnetic stimulation (rTMS) after acute stroke: A one-year longitudinal randomized trial.

YZ, Guan; J, Li; XW, Zhang; S, Wu; H, Du; LY, Cui; WH, Zhang

Abstract:

AIMS: To evaluate the effectiveness of repetitive transcranial magnetic stimulation (rTMS) on motor recovery after stroke using a prospective, double-blind, randomized, sham-controlled study. METHODS: Patients with unilateral subcortical infarction in the middle cerebral artery territory within 1 week after onset were enrolled. The patients were randomly divided into an rTMS treatment group and a sham group. We performed high-frequency rTMS or sham rTMS on the two groups. Motor functional scores were assessed pre- and post-rTMS/sham rTMS and at 1 month, 3 months, 6 months, and 1 year after stroke onset. The scores included the National Institutes of Health Stroke Scale (NIHSS), Barthel Index (BI), Fugl-Meyer Assessment Upper Limb/Lower Limb (FMA-UL/LL), modified Rank Score (mRS), and the resting motor threshold (RMT) of the hemiplegic limb. RESULTS: At baseline, no significant differences were found between the two groups for motor functional scores. On the second day after rTMS treatment, score improvements of the NIHSS, BI, FMA-UL in the real treatment group were more significant than those in the sham group. In addition, similar results were obtained at 1 month. However, at 3 months, 6 months, and 1 year after onset, no significant differences in improvement were observed between the two groups, except for the FMA-UL score improvement. CONCLUSION: rTMS facilitates motor recovery of acute stroke patients, and the effect can last to 1 month, except the function improvement on upper extremities could last for 1 year. A single course of rTMS in the acute stage may induce the improvement of upper extremities function lasted for 1 year.

Patologie/Applicazioni:

• Stimolazione Magnetica Transcranica (TMS)
• Stroke
• Double blind

Anno:

2017

Tipo di pubblicazione:

Articolo

Parola chiave:

double blind; Stroke; stimolazione magnetica transcranica

Testata scientifica:

CNS Neuroscience and Therapeutics

Nota:

I pazienti sono stati divisi casualmente in un gruppo di trattamento rTMS e un gruppo sham. Al basale, non sono state trovate differenze significative nelle funzioni motorie tra i due gruppi.

DOI:

10.1111/cns.12762